TABLE 1: Rodent MAP v. 1.5 Antigen panel comparison of mean analyte values from mouse serum vs. mouse plasma. Light Green shading = serum to plasma ratio greater than 1.5; Blue shading = serum to plasma ratio less than 0.5.

Analyte	LDD	Units	Serum Mean	Plasma Mean	Serum/Plasma
Apo A1	10	ug/ml	117	109	1.08
CD40	12	pg/ml	208	132	1.57
CD40 L	92	pg/ml	485	424	1.15
CRP*	0.53	ug/ml	0.27	0.42	0.65
EGF	39	pg/ml	20.8	22.5	0.92
Endothelin-1	67	pg/ml	19.7	28.6	0.69
Eotaxin	12	pg/ml	808	907	0.89
Factor VII	0.96	ng/ml	1.00	0.95	1.06
FGF-9	0.99	ng/ml	0.77	0.23	3.38
FGF-basic	0.58	ng/ml	1.15	0.86	1.33
Fibrinogen	12	ug/ml	212	3989	0.05
GCP-2	0.025	ng/ml	19.5	4.8	4.06
GM-CSF	8.7	pg/ml	14.8	2.9	5.07
GH	4.2	ng/ml	20.0	10.2	1.96
GST-α	0.42	ng/ml	0.17	0.14	1.20
Haptoglobin	0.64	ug/ml	69.0	74.9	0.92
IFN-γ	68	pg/ml	57.6	6.7	8.61
IgA	1.9	ug/ml	153	109	1.40
IL-10	109	pg/ml	490	251	1.95
IL-11	87	pg/ml	46.4	40.8	1.14
IL-12p70	0.57	ng/ml	0.21	0.03	6.75
IL-17	0.15	ng/ml	0.03	0.01	3.00
IL-1α	45	pg/ml	311	88.6	3.51
IL-1ß	0.45	ng/ml	0.50	0.50	1.05
IL-2	67	pg/ml	19.5	14.1	1.39
IL-3	21	pg/ml	1.7	0.68	2.43
IL-4	74	pg/ml	18.7	12.7	1.47
IL-5	0.19	ng/ml	0.18	0.15	1.14
IL-6	14	pg/ml	385	142	2.71
IL-7	0.31	ng/ml	0.10	0.04	2.13
Insulin	2.0	uIU/ml	6.2	7.4	0.84
IP-10	40	pg/ml	554	136	4.09
KC/GROα	0.17	ng/ml	2.0	0.67	2.92
Leptin	0.096	ng/ml	2.6	3.7	0.69
LIF	44	pg/ml	169	119	1.42
Lymphotactin	85	pg/ml	191	106	1.80
MCP-1	17	pg/ml	1122	412	2.72
MCP-3	31	pg/ml	1072	542	1.98
MCP-5	46	pg/ml	266	143	1.86
M-CSF	0.018	ng/ml	4.6	3.8	1.22
MDC	22	pg/ml	512	346	1.48
MIP-1α	0.23	ng/ml	0.24	0.27	0.91
MIP-1ß	78	pg/ml	662	252	2.63
MIP-1γ	0.074	ng/ml	21.0	18.82	1.12
MIP-2	7.2	pg/ml	578	149	3.89
MIP-3ß	0.47	ng/ml	0.27	0.20	1.35
MMP-9	10	ng/mL	71.1	29.4	2.42
Myoglobin	24	ng/ml	1335	357	3.74
OSM	0.13	ng/ml	0.10	0.04	2.04
RANTES	48	pg/ml	33.2	6.2	5.33
SCF	75	pg/ml	114	57.3	2.00
SGOT	1.9	ug/ml	15.8	27.0	0.59
TIMP-1	0.18	ng/ml	4.2	3.1	1.35
TF	0.52	ng/ml	2.9	2.6	1.11
TNF-α	0.14	ng/ml	0.20	0.06	2.46
TPO	2.7	ng/ml	9.0	8.6	1.05
VCAM-1	0.95	ng/mL	1692	1532	1.10
VEGF	38	pg/ml	350	180	1.94
vWF	99	ng/ml	78.4	462	0.17

* This CRP assay was the first CRP assay utilized by RBM which was much more specific for rat CRP then mouse CRP. Version 1.6 of the Rodent MAP uses this rat CRP assay for rat samples and a mouse specific CRP assay for mouse samples.

TABLE 2: Analytes with greater than 1.5 ratio of analyte mean value in serum as compared with plasma.

Analyte	LDD	Units	Serum Mean	Plasma Mean	Serum/Plasma
CD40	12	pg/ml	208	132	1.57
GCP-2	0.025	ng/ml	19.5	4.8	4.06
GM-CSF	8.7	pg/ml	14.8	2.9	5.07
GH	4.2	ng/ml	20.0	10.2	1.96
IL-10	109	pg/ml	490	251	1.95
IL-1α	45	pg/ml	311	88.6	3.51
IL-6	14	pg/ml	385	142	2.71
IP-10	40	pg/ml	554	136	4.09
KC/GROα	0.17	ng/ml	2.0	0.67	2.92
Lymphotactin	85	pg/ml	191	106	1.80
MCP-1	17	pg/ml	1122	412	2.72
MCP-3	31	pg/ml	1072	542	1.98
MCP-5	46	pg/ml	266	143	1.86
MIP-1ß	78	pg/ml	662	252	2.63
MIP-2	7.2	pg/ml	578	149	3.89
MMP-9	10	ng/mL	71.1	29.4	2.42
Myoglobin	24	ng/ml	1335	357	3.74
SCF	75	pg/ml	114	57.3	2.00
TNF-α	0.14	ng/ml	0.20	0.06	2.46
VEGF	38	pg/ml	350	180	1.94

TABLE 3: Analytes with less than 0.5 ratio of analyte mean value in serum as compared with plasma.

Analyte	LDD	Units	Serum Mean	Plasma Mean	Serum/Plasma
Fibrinogen	12	ug/ml	211	3989	0.05
vWF	99	ng/ml	78.4	462	0.17