Simultaneous Analysis of Host and Pathogen Interactions during an in vivo Infection Reveals Local Induction of Host Acute Phase Response Proteins, a Novel Bacterial Stress Response, and Evidence of a Host-Imposed Metal Ion Limited Environment. 2004. S. Timothy Motley, Brian J. Morrow, Xuejun Liu, Ingrid J. Dodge, Antonella Vitiello, Christine K. Ward and Karen Joy Shaw. Johnson & Johnson Pharmaceutical Research and Development, La Jolla, CA. Cellular Microbiology 6(9):849-865.
LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response. 2004. Sean Joseph1, 4, Michelle Bradley1, 4, Antonio Castrillo1, 4, Kevin Bruhn2, Puiying Mak3, Liming Pei1, John Hogenesch3, Ryan O'Connell2, Genhong Cheng2, Enrique Saez3, Jeffery Miller2 and Peter Tontonoz 1, 1Dept. of Pathology and Laboratory Medicine, 2Dept. of Microbiology Immunology and Molecular Genetics, UCLA, Los Angeles, CA, 3Genomics Institute of the Novartis Research Foundation, San Diego, CA. Cell 119(2):299-309.
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. 2004. Heuer, Josef G. PhD; Sharma, Ganesh R. BS; Gerlitz, Bruce MS; Zhang, Tonghai MS; Bailey, Dianna L. RVT; Ding, Chunjin MS; Berg, David T. BS; Perkins, Douglas MS; Stephens, Eddie J. BS; Holmes, Kimberly C. LATG; Grubbs, Renee L. RVT; Fynboe, Kelly A. BS; Chen, Yun-Fei PhD; Grinnell, Brian PhD; Jakubowski, Joseph A. PhD. Eli Lilly and Company Discovery Research Laboratory, Indianapolis, IN. Critical Care Medicine. 32(7):1570-1578.
Mkks-null mice have a phenotype resembling Bardet–Biedl syndrome. Melissa Fath1,5, Robert Mullins2, Charles Searby1,5, Darryl Nishimura1,5, Jun Wei1,5, Kamal Rahmouni3, Roger Davis1, Marwan Tayeh1, Michael Andrews1,5, Baoli Yang4, Curt Sigmund3, Edwin Stone2,5 and Val Sheffield1,5. 1Dept. of Pediatrics, Division of Medical Genetics, 2Dept. of Ophthalmology, 3Dept. of Internal Medicine, 4Dept. of Obstetrics and Gynecology and 5Howard Hughes Medical Institute, University of Iowa, Iowa City, IA. Human Molecular Genetics 2005 14(9):1109-1118.
Hypoxia-induced Neutrophil Survival is Mediated by HIF-1?B Activity. 2005. Sarah R. Wamsley1, Christin Print2, Neda Farahi1, Carole Peyssonnaux3, Randall S. Johnson3, Thorsten Cramer3, Anastasia Sobelewski1, Alison M. Condliffe1, Andrew S. Cowburn1, Nicola Johnson2, and Edwin R. Chilvers1. 1Division of Respiratory Medicine, 2Dept. of Pathology, University of Cambridge, Cambridge, UK, 3Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA. Journal of Experimental Medicine. 201(1):105-115.
Multiplex proteomic approaches to sepsis research: case studies employing new technologies. 2005. Josef G Heuer, David J Cummins and Brian T Edmonds. Biotechnology Discovery Research, Eli Lilly and Company, Indianapolis, IN. Expert Review of Proteomics, Oct 2005, 2(5): 669-680.
Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis. 2005. Josef Heuer1, Tonghai Zhang1, Jingyong Zhao2, Chunjin Ding1, Martin Cramer1, Kathy Justen2, Steven Vonderfecht1, and Songqing Na2. 1Biotechnology Discovery Research, 2Bone and Inflammation, Eli Lilly and Company, Indianapolis, IN. The Journal of Immunology. 174: 7141-7146.
Prophylactic Administration of Abatacept Prevents Disease and Bone Destruction in a Rat Model of Collagen-Induced Arthritis. 2005. C. Kliwinski, D. Kukral, J. Postelnek, B. Krishnan, L. Killar, A. Lewin, S. Nadler, and R. Townsend. Bristol-Myers Squibb, Princeton, NJ. Journal of Autoimmunity 25:165-171.
Effects of Hyperglycemia and Insulin Therapy on Outcome in a Hyperglycemic Septic Model of Critical Illness. 2006. Josef Heuer, Ganesh Sharma, Tonghai Zhang, Chunjin Ding, Dianna Bailey, Eddie Stevens, Kimberly Holmes, Renee Grubbs, Kelly A. Fynboe, Yun-Fei Chen, and Joseph Jakubowski. Biotechnology Discovery Research, Eli Lilly and Company, Indianapolis, IN. The Journal of Trauma, Injury, Infection and Critical Care 60(4): 865-872.
Murine Embryonic Stem Cells Secrete Cytokines/growth modulators that Enhance Cell Survival/anti-apoptosis and Stimulate Colony Formation of Murine Hematopoietic Cells. 2006. Y. Guo, B. Graham-Evans, and H. Broxmeyer. Dept. of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN. Stem Cells 24(4):850-856. Proceedings Part I. Vol 24, No. 18S (June 20 Supplement): 8010.
Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity. 2006. Gregory Dietsch 1, Chris DiPalma 1, Russell Eyre 1, Tuan Pham 1, Karen Poole 1, Noah Pefaur 2, William Welch 1, Esther Trueblood 1, William Kerns 3, Suzanne Kanaly 1. 1 ICOS Corporation, Bothell, Washington, 2 ICOS Corporation, currently at Pacific Northwest National Laboratories, Richland, Washington, 3 Pharma Consulting, Harvard, Boston, MA. Toxicologic Pathology. 34(1): 39-51.
TWEAK is a Novel Arthritogenic Mediator. 2006. Stuart Perper1, Beth Browning1, Linda Burkly1, Shawn Weng1, Cindy Gao1, Keith Giza1, Lihe Su1, Leticia Tarilonte1, Thomas Crowell1, Luis Rajman1, Laura Runkel1, Martin Scott1, Gerald Atkins2, David Findlay2, Timothy Zheng1,2, and Henry Hess1. 1Biogen Idec, Cambridge, MA, 2Dept. of Orthopedics and Trauma, University of Adelaide, Adelaide, Australia. J. Immunol 177:2610-2620.
A Phase II Pilot Trial of Low Dose, Continuous Infusion, or “Metronomic”, Paclitaxel and Oral Celecoxib in Patients with Metastatic Melanoma. 2006. D. McDermott, D. Cho, J. Merchan, R. Bhatt, V. Seery, J. Mosher, M. Farquhar, M. Atkins and V. Sukhatme. Renal Division, Beth Israel Deaconess Medical Cntr., Boston, MA. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement): 8010.
Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective. 2006. Mallika Singh and Leisa Johnson . Genentech, Inc., South San Francisco, California. Clinical Cancer Research (12): 5312-5328, September 15, 2006.
Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex. 2006. Dean Toy, David Kugler, Martin Wolfson, Tim Vanden Bos, Jesse Gurgel, Jonathan Derry, Joel Tocker and Jacques Peschon. Departments of Inflammation, Protein Sciences, Oncology, and Molecular Sciences, Amgen, Seattle WA . The Journal of Immunology. 177: 36-39.
Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1 (+/-) mice. 2006. David L Basi1, Neeta Adhikari2, Ami Mariash3, Qinglu Li4, Esther Kao4, Sureni V Mullegama4, and Jennifer L Hall2. 1 Developmental/Surgical Science, 2Medicine/Cardiology, 3 Developmental/Surgical Science, 4 Medicine, University of Minnesota, Minneapolis, Minnesota. Am J Physiol Heart Circ Physiol.2006; 0: 00246.2006v1.
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. 2006. S. Schilling, S. Goelz, R. Linker, F. Luehder and R. Gold. Institute for Multiple Sclerosis Research, University of Goettingen, Goettingen, Germany and BiogenIdec Cambridge, MA, USA. Clinical and Experimental Immunology. 145(1):101.
The metabolic state of diabetic monkeys is regulated by FGF-21. 2006. Alexei Kharitonenkov, Victor J. Wroblewski, Anja Koester, Yun-Fei Chen, Cathleen K. Clutinger, Xenia T. Tigno, Barbara C. Hansen, Armen B. Shanafelt, and Garret J. Etgen. Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN (A.K.,V.J.W., A.K., Y.-F.C., C.K.C., A.B.S., G.J.E.); The Obesity, Diabetes and Aging Research Center, Departments of Internal Medicine and Pediatrics, College of Medicine, University of South Florida, Tampa, FL (X.T.T., B.C.H.). Endocrinology, doi:10.1210/en.2006-1168.
Strain Differences Influence Murine Pulmonary Responses to Stachybotrys chartarum. 2006. Jamie H. Rosenblum Lichtenstein, Ramon M. Molina, Thomas C. Donaghey and Joseph D. Brain. Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts. American Journal of Respiratory Cell and Molecular Biology. Vol. 35, pp. 415-423, 2006.
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results. 2006. Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C. Istituto di Biofisica, CNR, Pisa, Italy. Biomed Pharmacother. 2006 Sep;60(8):463-7.
Sirtuin regulates cigarette smoke induced pro-inflammatory mediators release via RelA/p65 NF- B in macrophages in vitro and in rat lungs in vivo. 2006. Se-Ran Yang1, Jessica Wright1, Mark Bauter1, Kathryn Seweryniak1, Aruna Kode1, and Irfan Rahman1. Environmental Medicine, University of Rochester, Rochester, New York, United States. Am J Physiol Lung Cell Mol Physiol 292: L567-L576, 2007.
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection. 2006. Corinna W. Knorr1, Stanley D. Allen1, Anthony R. Torres2 and Donald F. Smee1, 1Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, 2Center for Persons with Disabilities, Utah State University, Logan, Utah. Antiviral Research 72(2): 125-133 (2006).
Testing the Viability of Stored Frozen Serum Samples from the Air Force Health Study using Human Multi-Analyte Profiles (MAPs) 2006. K. A. Fox1 and M. Pavuk2, 1 USAF School of Aerospace Medicine, Brooks City-Base, San Antonio, TX, 2 SpecPro Inc., 12500 San Pedro Ave., Suite 670, San Antonio, TX. Organohalogen Compounds 68(206):1390-1393 (2006).
Modeled Gravitational Unloading Induced Downregulation of Endothelin 1 in Human Endothelial Cells. 2007. Manfred Infanger1, Claudia Ulbrich2, Sarah Baatout3, Markus Wehland2, Reinhold Kreutz2, Johann Bauer4, Jirka Grosse2, Sonia Vadrucci5, Augusto Cogoli5, Hanane Derradji3, Mieke Neefs3, Sabine Küsters6, Mike Spain6, Martin Paul2 and Daniela Grimm2. 1Department of Trauma and Reconstructive Surgery and 2Institute of Clinical Pharmacology and Toxicology, Charité-University Medical School, Campus Benjamin Franklin, Center of Space Medicine, Berlin, Germany, 3Laboratory of Radiobiology and Microbiology, Belgian Nuclear Research Centre, Mol, Belgium, 4Max-Planck Institute of Biochemistry, Martinsried, Germany, 5Zero-g Lifetec GmbH and Space Biology Group, ETH Zurich, Switzerland, 6Rules Based Medicine, Austin, Texas, USA. Journal of Cellular Biochemistry 9999:1-17.
Multi-Analyte Profiling of Post-Myocardial Infarction Plasma Samples. 2007. G. Patricia Escobar and Merry L. Lindsey. Medicine/Cardiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX. The FASEB Journal 21:746.
Neighboring Adipocytes Participate in the Bone Marrow Microenvironment of Multiple Myeloma Cells. 2007. J Caers1, S. Deleu1, Z. Belaid2, H De Raeve3, E Van Valckenborgh1,E. De Bruyne1, M-P DeFrense2, I Van Reit1, B Van Camp1, and K. Vanderkerken1. 1Laboratory of Hematology and Immunology, Vrije Universiteit Brussels, Brussels, Belgium, 2Laboratory of Histology and Cytology, Universite de Liege, Liege, Belgium, 3 Department of Pathology, Antwerp University, Antwerp, Belgium. Leukemia 21:1580-1584.
Activated Protein C Ameliorates LPS-induced Acute Kidney Injury and Downregulates Renal INOS and Angiotensin 2. 2007. A. Gupta1, G. Rhodes2, D Berg1, B. Gerlitz1, B. Molitoris2, and B Grinell1. 1 Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis and 2 Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN. Am J Physiology Renal Physiology 293:F245-F254.
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. 2007. Ryotaro Sakamori 1 , Tetsuo Takehara 1 , Chihiro Ohnishi 1, Tomohide Tatsumi 1, Kazuyoshi Ohkawa 1, Kiyoshi Takeda 2, Shizuo Akira 3, Norio Hayashi 1. 1Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan, 2Department of Molecular Genetics, Medical Institute of Bioregulation, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. Hepatology 46( 5): 1564 – 1573.
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. Hal Blumberg1, Huyen Dinh1, Esther S. Trueblood2, James Pretorius4, David Kugler1, Ning Weng3, Suzanne T. Kanaly2, Jennifer E. Towne1, Cynthia R. Willis1, Melanie K. Kuechle5, John E. Sims1, and Jacques J. Peschon1. 1 Department of Inflammation, 2 Department of Pathology, 3 Department of Biostatistics, Amgen, Seattle, WA, 4 Department of Pathology, Amgen, Thousand Oaks, CA, 5 Department of Dermatology, University of Washington School of Medicine, Seattle, WA. The Journal of Experimental Medicine 204(11): 2603-2614.
Phase I study of eptifibatide in patients with sickle cell anaemia. 2007. Sheritha P. Lee1, Kenneth I. Ataga2, Mohamed Zayed1, Jeanne M. Manganello3, Eugene P. Orringer2, David R. Phillips3 and Leslie V. Parise1,4. Departments of 1Pharmacology, 2Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Millennium Pharmaceuticals, South San Francisco, CA and, 4Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. British Journal of Haematology 139 (4), 612–620.
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. 2007. Jason S Stumhofer1, Jonathan S Silver1, Arian Laurence2, Paige M Porrett3, Tajie H Harris1, Laurence A Turka3, Matthias Ernst4, Christiaan J M Saris5, John J O'Shea2 & Christopher A Hunter1. 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 2 Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Muskoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, 3Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 4Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia, 5Department of Inflammation Research, Amgen, Thousand Oaks, California. Nature Immunology 8:1363 – 1371.
Lysosomal Dysfunction Results in Altered Energy Balance. 2007. Josh C. Woloszynek , Trey Coleman , Clay F. Semenkovich, and Mark S. Sands. Departments of Medicine, Genetics, and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO. J. Biol. Chem.282(49): 35765-35771, December 7, 2007.
Inflammatory Biomarkers in the Systemic Inflammation Response Syndrome (SIRS): Are There Differences in Patients that Become Septic? Steven Johnson1, Alan Cross1, Jeffrey Hasday1, Grant Bochicchio1, Carl Stanholtz1, Michael Towns2, and Richard Moore. 1R. Adams Cowley Trauma Center, University of Maryland, Baltimore MD, 2BD Diagnostic Systems, Sparks, MD. Presented at the Society of Critical Care Medicine, January 2005, Phoenix, AZ.
Multi-Analyte Immunoassay Profiles of Plasma Biomarkers of Inflammatory Change in a Rat Model of Early Mesenteric Vascular Injury. P. O’Brien, S. Chevalier, E. Schenck, V. Pawlowski, N. Dagues, and D. Ledieu. Safety Sciences Europe, Pfizer, Sandwich, UK and Amboise, France. Presented at the 5th International Colloquium on Animal Acute Phase Proteins, March 2005, Dublin, Ireland.
Application of a Multi-Analyte Profile to Assess Organophosphate Induction of Pro-inflammatory and Pro-atherosclerotic Proteins in Rats. Cina Mack, P. Becker and C.J. Gordon. Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC. Presented at Experimental Biology, April 11-14, 2005, San Diego, CA.
Large Multi-Analyte Profile (MAP) Analyses Used to Identify Biomarkers Attributable to Extreme Physical Exercise. Jim Mapes, Josh Kemp, Margaret Sandefur, Carroll Casey, Dennis Denton, Mauricio Gamboa, Dale Frazier, and Laura Bartaszewicz. Rules-Based Medicine, Inc., Austin, TX. Presented at the Oak Ridge Conference, April 14-15, 2005, Baltimore, MD.
Proteomic Analysis of Human Serum Samples: Evaluation of Dry State Protein Archiving System. Sue-Jane Chen1, Gongyi Shi2, Ellen Schwegler3, Shannon Winchester1, Bonnie Iverson1, Jim Davis1, Michael Hogan1, and Richard Drake3. 1GenVault Corporation, Carlsbad, CA, 2Bruker Daltonics, Inc., Fremont, CA, 3Eastern Virginia Medical School, Norfolk, VA. Presented at Pep Talk, January 9-13, 2006, San Diego, CA.
Identification of Plasma Markers for ob/ob and Diet-Induced Obese (DIO) Mice Through the Use of Multi-Analyte Immunoassay Panels. Martin Voorbach1, John Wass2, Denise Wilcox1, Phong Nguyen1, Paul Jung2, Paul Kroeger2, Regina Reilly1, Peer Jacobson1, and Katherine Landschulz1. 1Metabolic Disease Research, 2Advanced Technology, Abbott Laboratories, Abbott Park, IL,. Presented at the Keystone Series: Diabetes Mellitus and the Control of Cellular Energy Metabolism. January 24, 2006, Vancouver, BC.
Decreased Heart Rate is Associated with Carbamate-Induced Activation of Pro-Inflammatory Serum Proteins. Cina Mack, P. Becker and C.J. Gordon. Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC. Presented at Experimental Biology, April 01-04, 2006, San Francisco, CA.
TGF-b, pSMAD and TGF-b-related Markers in Patients with Advanced Metastatic Cancer. Jose Baselga1, Mace Rothenberg2, Joseph Tabernero1, Joan Seoane1, Thomas Daly3, Ann Cleverly3, Brandi Berry3, Susanne Kloeker3, Lisa Anne Wallace4, Jonathan Yingling3, Michael Lahn3, Carlos Arteaga2 and Michael Carducci4. 1Vall d´Hebron University Hospital, Barcelona, Spain, 2Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, 3Eli Lilly and Company Research Laboratories, Indianapolis, IN, 4The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD. Presented at the American Association for Cancer Research, April 1-5, 2006, Washington, DC.
Presyndromic Detection of Host Response Biomarkers in a Mouse Cowpox Model. Michael Ascher1, Richard Langlois1, Kenneth Turteltaub1, Kevin McLoughlin1, and Richard Lyons2, 1Lawrence Livermore National Laboratory, Livermore, CA and 2University of New Mexico Health Sciences Center, Albuquerque, NM. Presented at the American Society for Microbiology Annual Meeting, May 21-25, 2006, Orlando, FL.
The Potential of Multi-Analyte Genomic and Protein Profiling in Apheresis Medicine: Diagnostic and Therapeutic Considerations. Margaret O’Toole, Wyeth Research, Cambridge, MA. Presented at the American Association for Apheresis Annual Meeting, May 23-26, 2006, Las Vegas, NV.
Testing the Viability of Stored Frozen Stored Serum Samples from the Air Force Health Study using Human Multi-Analyte Profiles (MAPs), K. A. Fox and M. Pavuk, Brooks City-Base, San Antonio, TX. Presented at the 26th International Symposium on Halogenated Persistent Organic Pollutants, August 21-25, 2006, Oslo, Norway.
Proteomic Pattern and Cytokines Concentration in Cancer Patients During Chemotherapy: Effects of the Incubation in vitro with a Styrenic Divinylbenzene Resin. . 2006. Mary Lou Wratten1, Francesco Piccolomini2, Luisa Sereni1, Ettore Balestreri2, Elena Donadio3, Antonio Felicioli3, Romano Felicioli2, and Carlo Donadio4. 1Bellco, Scientific Affairs, Mirandola; 2Instituto di Biofisica, CNR, Pisa; 3Dipartmento di Anatomia, Biochimica e Fisiologia Veterinaria, Universita, Pisa; 4Dipartmento di Medicina Interna, Universita, Pisa. Presented at The Italian Proteomic Association, !st Annual National Meeting, July 2-4, 2006, Pisa, Italy.
Identification of Diagnostic Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Peripheral Samples from Case/Control Collections Presented at The Biomarkers Discovery and Development Congress, February 26th-27th, 2007, Manchester, UK.
Transition to an Unstable Coronary Syndrome is Marked by Hypercoagulability, Platelet Activation, Heightened Platelet Reactivity and Inflammation: Results of the Thrombotic RIsk Progression (TRIP) Study. Udaya Tantry, Kevin Bliden, Rolf Krentz, Joseph DiChiara and Paul Gurbel. Sinai Center for Thrombosis Research, Sinai Hospital, Baltimore, MD. Presented at The American College of Cardiology Annual Scientific Session, March 24-27, 2007, New Orleans, LA.
Inhibition of the Inflammatory Process by n-3 PUFA in colonic cells of transgenic mice. Claudia Gravghi, Krista Perle, Jing Kang, Fred Quimby, Winfred Edelmann, Martin Lipkin, Lisa Hudgins, Sergio Lamprecht. Strang Cancer Center, NY,NY, Memorial Sloan Kettering Cancer Center, NY,NY, Harvard Medical School, Boston, MA, The Rockefeller University, NY,NY, Albert Einstein College of Medicine, Bronx, NY. Presented at the American Association for Cancer Research, April 14-18, 2007, Los Angeles, CA.
The Way to Safety Biomarkers: Holy Grail of Toxicology. Thomas Herget, New Technology Evaluation, Merck KGaA, Darmstadt, Germany. Presented at the Marcus Evans Discovery Summit, April 2-4 2007, Monte Carlo, Monoco.
A central role for Interleukin 27 and 6 mediated activation of STAT3 in T cell production of Interleukin 10. Jason S. Stumhofer1, Jonathan S. Silver1, Arian Laurence2, Paige M. Porrett3, Tajie H. Harris1, Laurence A. Turka3, Matthias Ernst4, Christiaan JM Saris5, John J. O¢Shea2 and Christopher A. Hunter1. 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 2Molecular Immunology & Inflammation Branch, National Institute of Arthritis & Muskoskeletal & Skin Diseases, National Institutes of Health, Bethesda, 3Department of Medicine, University of Pennsylvania, 4Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia, 5Department of Inflammation Research, Amgen, Thousand Oaks, CA 91320. Presented at the 15th Annual Meeting of the International Cytokine Society, October 26-30, 2007, San Francisco, CA.
Diagnosis of Sepsis or SIRS Using Biomarker Profiles. Richard M. Ivey et al. 2004. Becton Dickinson and Co., Franklin Lakes, NJ. US patent No. US 20040096917.
Creation of a database of biochemical data and methods of use. Mark Chandler et al. 2004. Rules-Based Medicine, Inc., Austin, TX. US Patent No. US 20040267568.
Methods and Kits for the Diagnosis of Acute Coronary Syndrome. 2005. J. Mapes and M. Spain. Rules-Based Medicine, Inc., Austin, TX. Filed in Sept., 2005.
Methods and Kits for the Diagnosis of Hypothyroidism. 2006. J. Mapes and M. Spain. Rules-Based Medicine, Inc., Austin, TX. Filed in Dec., 2006.
Methods and Kits for the Diagnosis of Stroke. 2006. J. Mapes and M. Spain. Rules-Based Medicine, Inc., Austin, TX. Filed in Dec., 2006.
Stable protein storage and stable nucleic acid storage in recoverable form. 2006. M. Hogan and James Davis. US Patent No. 20060014177.
Modeling of Systematic Inflammatory Response to Infection, 2006. V. Antonia and Z. Yi. Janssen Pharmaceuticals, NV, International Patent No. WO2005048823.
Diagnosis of sepsis. 2006. James A.Garrett, Sha-Sha Wang, Keith Thornton, Richard Moore, William Keating, William Nussbaumer and Craig Whiteford. US Patent No. 20060246495.
Methods and Kits for the Diagnosis of Galactosemia. 2006. J. Mapes and M. Spain. Rules-Based Medicine, Inc., Austin, TX. Filed in Jan., 2007.
Methods and Kits for the Diagnosis of Sickle Cell Anemia. 2007. J. Mapes, M. Spain, R. McDade and K. Pass. Rules-Based Medicine, Inc., Austin, TX. Filed in Feb., 2007.
Methods and Kits for the Diagnosis of Neonatal Sepsis. 2007. J. Mapes, M. Spain, R. McDade and K. Pass. Rules-Based Medicine, Inc., Austin, TX. Filed in Feb., 2007.
Method for Rapid Disease Screening. 2007. J. Mapes, M. Spain, C. Benson and R. McDade. Rules-Based Medicine, Inc., Austin, TX. Filed in Mar., 2007.
Recombinant Polyclonal Antibody for Treatment of Respiratory Syncytial Virus Infections. 2007. Lantto, Johan Bryggaregatan, 4, SE-227 36 Lund (SE), Steinaa, Lucilla, Stenhavevej 12B, DK-2970 Hørsholm (DK), Koefoed, Klaus, Tom Kristensvej 42, 7. tv., DK-2300 Copenhagen S (DK), Nielsen, Lars, S., Nivåpark 58, DK-2990 Nivå (DK), Nielsen, Henriette, Schjønning, Ravnehusparken 34, DK-3400 Værloese (DK). Filed March 6, 2007.
|
Rules-Based Medicine, Inc. | 3300 Duval Road • Austin, TX 78759 • T: 866-RBM-MAPS • F: 512-835-4687 • E: info@rbmmaps.com |